Synergistic Effects and Decreasing Toxicity of Sarcandra Glabra Essential Oils on Tumor-bearing Mice Treated by Cytoxan / 浙江中医药大学学报

ABSTRACT

[Objective] To study synergistic effect and decreasing toxicity of Sarcandra Glabra essential oils (SGE) on H22 and S180 bearing mice treated with cytoxan (CTX).[Method] Transplanting H22 and S180 mice tumor models were established to observe the tumor inhibiting rate when SGE was used in combination with CTX by two different routes of administration.While the inhibition effects of SGE in decreasing blood platelet,leukocyte and hemoglobin induced by CTX were also detected.[Result] SGE has anti-tumor and synergy effect when combined with CTX on H22 and S180 bearing mice.The H22 and S180 tumor inhibiting rates of CTX (10mg?kg-1 or 15mg?kg-1) combined with SGE (36.6mg?kg-1) by iv.were increased compared with using CTX alone (P