Sentinel Lymph Node in Breast Cancer: Review Article from a Pathologist's Point of View
Journal of Pathology and Translational Medicine
;
: 83-95, 2016.
Article
in English
| WPRIM
| ID: wpr-56492
ABSTRACT
Breast cancer staging, in particular N-stage changed most significantly due to the advanced technique of sentinel lymph node biopsy two decades ago. Pathologists have more thoroughly examined and scrutinized sentinel lymph node and found increased number of small volume metastases. While pathologists use the strict criteria from the Tumor Lymph Node Metastasis (TNM) Classification, studies have shown poor reproducibility in the application of American Joint Committee on Cancer and International Union Against Cancer/TNM guidelines for sentinel lymph node classification in breast cancer. In this review article, a brief history of TNM with a focus on N-stage is described, followed by innate problems with the guidelines, and why pathologists may have difficulties in assessing lymph node metastases uniformly. Finally, clinical significance of isolated tumor cells, micrometastasis, and macrometastasis is described by reviewing historical retrospective data and significant prospective clinical trials.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Breast
/
Breast Neoplasms
/
Prospective Studies
/
Retrospective Studies
/
Classification
/
Sentinel Lymph Node Biopsy
/
Neoplasm Micrometastasis
/
Joints
/
Lymph Nodes
/
Neoplasm Metastasis
Type of study:
Practice guideline
/
Observational study
Language:
English
Journal:
Journal of Pathology and Translational Medicine
Year:
2016
Type:
Article
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