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Effects of Rosiglitazone on Express of Nuclear Factor-kappa B in Peripheral Blood Mononuclear Cells of Multiple Organ Dysfunction Syndrome Rats / 医学研究杂志
Article in Chinese | WPRIM | ID: wpr-565016
Responsible library: WPRO
ABSTRACT
Objective To investigate the effects of rosiglitazone,an agonist of proliferators activated receptor?(PPAR?),on expression of nuclear factor-kappa B(NF-?B)in peripheral blood mononuclear cells(PBMC)of multiple organ dysfunction syndrome(MODS) rats.Methods Forty male SD rats were randomly divided into four groups(n = 6 per group) vehicle control group,endotoxin(LPS) group,rosiglitazone(ROSI) pretreatment group,and PPAR-?antagonist GW9662 pretreatment group.Blood was taken 4 hours after operation,and mononuclear cells were separated.The expression of NF-?B p65in PBMC was detected by immunocytochemical method and image analysis was carried out.Results The expression of NF-?B p65 was low in vehicle control group.In LPS group,the expression of NF-?B p65 was significantly higher than that in vehicle control group(P0.05).Conclusion Rosiglitazone protected the MODS rats by inhibiting NF-?B activation.

Full text: Available Index: WPRIM (Western Pacific) Language: Chinese Journal: Journal of Medical Research Year: 2006 Type: Article

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Full text: Available Index: WPRIM (Western Pacific) Language: Chinese Journal: Journal of Medical Research Year: 2006 Type: Article