Clinical Significance of the Correlation Between Serum Hepatocyte Growth Factor and Urinary Viable Tubular Cells Count in Patients with Acute Renal Failure / 医学研究杂志

ABSTRACT

Objective To study the correlation between serum hepatocyte growth factor and Urinary viable tubular cells count in patients with acute renal failure and to evaluate the clinical significance.Methods Serum HGF levels were determined by ELISA and the number of viable tubular cells in urine was determined by trypan blue in 25 patients with ARF at the stages of oliguria,polyuria and convalescence.The relationship between serum HGF levels,the number of viable tubular cell and renal function was studied.Results Compared with the 9th day from the occurrence of ARF,the HGF levels in the serum increased significantly at the 1th day in the ARF patients.There was significant positive correlation between BUN or SCr and the serum HGF in urine in patients with acute renal failure.Conclusion Serum HGF in ARF patients increased significantly and tended to rise at first but dropped afterwards,which reflected the course of renal injury and the recovery of renal epithelial cells.The detected viable tubular cells in urine were an early predictive indication of renal function recovering in ARF patients.