Correlation between of G protein-coupled receptor kinases 4 polymorphism and essential hypertension:a Meta-analysis / 第三军医大学学报
Journal of Third Military Medical University
;
(24)1983.
Article
in Chinese
| WPRIM
| ID: wpr-565041
ABSTRACT
Objective To access the relationship between the polymorphism of G protein-coupled receptor kinases 4(GRK4,including R65L,A486V and A142V) and essential hypertension.Methods All the literature on the subjects was searched by keywords such as essential hypertension,hypertension,G protein-coupled receptor kinases 4 gene,and polymorphism in the electronic databases,Medline of Year 1997 to 2006.RevMan 4.2 software was used for Meta analysis.Results A total of 857 cases and 913 controls from 4 studies were included.The ORs of genotypes of R65L,A142V and A486V were 0.97(0.75 to 1.25,P=0.81),0.81(0.30 to 2.08,P=0.65) and 1.48(1.16 to 1.8,P=0.001) respectively.Conclusion GRK4 gene polymorphism A486V is significantly associated with susceptibility of essential hypertension.People who carries A486V have a higher risk to be subject to essential hypertension.
Full text:
Available
Index:
WPRIM (Western Pacific)
Type of study:
Systematic reviews
Language:
Chinese
Journal:
Journal of Third Military Medical University
Year:
1983
Type:
Article
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