Effect of Biqi capsule on human cartilage glycoprotein-39 in peripheral blood monouclear cells in rheumatoid arthritis / 中华中医药杂志

ABSTRACT

Objective:To observe the effect of Biqi capsule on human cartilage glycoprotein-39 in peripheral blood monouclear cells,research the possible mechanism of Biqi capsule.Methods: 39 patients with RA and 10 healthy people were selected.Expression levels of human cartilage glycoprotein-39(HCgp-39) mRNA in peripheral blood monouclear cells(PBMC) were detected by Rt-PCR method.Results: Obvious expression of HCgp-39 mRNA was found in patients with RA,the relative expression quantity was(0.7920?0.5240),which has a signifi cant difference(0.3104?0.2519,P=0.024) compared with the healthy controls;expression levels of the HCgp-39 mRNA after treatment were signifi cantly decreased,there were statistically signifi cant differences(0.4755?0.2431,P=0.038) between pre and post treatment.Conclusions: The HCgp-39 mRNA in PBMC of patients with RA were obviously higher than that of healthy ones.These data supported a correlation between the activity of RA and the HCgp-39 mRNA in PBMC;there was a certain fall in the expression levels after treatment,which hinted the immunological regulation of Biqi capsule.