Effect of Alcohol Administration on Production of Cytokines, Salmonella Infection and Penicillin V - Induced Anaphylaxis in Mice / 대한면역학회지
Korean Journal of Immunology
;
: 61-68, 1998.
Article
in Korean
| WPRIM
| ID: wpr-56520
ABSTRACT
The present study was undertaken to investigate the effect of acute administration of ethanol on production of cytokines such as IL-1j3, IL-2, IL-6, IL-10 and TNF-a, induction of penicillin V-induced active fatal anaphylaxis, and resistence to Salmonel/a typhimurium infection in mice. Ethanol administration into mice was performed by intraperitoneal injection of 0.5 ml of 20 % ethanol for 3 consecutive days before induction of cytokines with lipopolysaccharide (LPS), Con A or Salmone/la injection. Serum levels of cytokines were measured by ELISA. It was found that ethanol administration significantly inhibited both the serum levels of all cytokines examined and the resistance of mice to S. typhimurium. However, ethanol administration failed to prevent penicillin-induced fatal anaphylaxis. Taken together, the present results may need new insights in the diagnosis and treatment of various immunologically-mediated diseases.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Penicillins
/
Salmonella
/
Salmonella Infections
/
Enzyme-Linked Immunosorbent Assay
/
Cytokines
/
Interleukins
/
Interleukin-6
/
Interleukin-2
/
Interleukin-10
/
Penicillin V
Type of study:
Diagnostic study
Limits:
Animals
Language:
Korean
Journal:
Korean Journal of Immunology
Year:
1998
Type:
Article
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