Effects of ?-3 polyunsaturated fatty acids on bone biomechanics in ovariectomized rats / 肠外与肠内营养

ABSTRACT

Objective:To explore the benefit effects of ?-3 polyunsaturated fatty acids on bone biomechanics in ovariectomized(OVX) rats.Methods: 60 virgin female Sprague-Dawley rats were randomized by the stratified weight method into 6 groups ① Sham groupdeionized water 2 mL/d;②OVX groupdeionized water 2 mL/d;③E2 group OVX +17?-ethinylestradiol 0.1 mg/(kg?d);④ A group OVX+?-3 PUFAs 75 mg/(kg?d);⑤B group OVX+?-3 PUFAs 150 mg/(kg?d);⑥ C group OVX+?-3 PUFAs 300 mg/(kg?d).Each group had 10 rats.After feeding for 90 days,the rats were killed and femur were separated.The maximum load,maximum deformation,elastic load,elastic deformation and energy absorption were measured from three point bending test.Bone wet weights were measured.Result: The femur biomechanics markers of OVX group decreased obviously,while that of all medicated group increased obviously(P