Skin Toxicity Effects of Common Disinfectants of Barrier Environment on Laboratory Animals / 医学研究杂志

ABSTRACT

Objective To observe the toxic reaction caused by short time contact with some common disinfectants such as 0.2% sodium hypochlorite,2%acetic acid and 2% glutaraldehyde and0.2%acetic acid,through wounded skin of laboratory animals and laborers.Methods Toxicity experiments of these disinfectants by artificial skin wound were carried on in guinea pigs,and the poisoning performance and the death situation of guinea pigs were observed.Results Light edema was caused by using 2% acetic acid,and the symptom disappeared after 3 days;it appeared the symptom of red bump and hemorrhagic spots after use 2% glutaraldehyde,and ecdysis occured after 4days,the red bump disappeared after 5 days with a brownish discoloration left;it didn't appear any toxic reaction by using 0.2% sodium hypochlorite and 0.2%acetic acid.Conclusion There was toxic effect of 2% acetic acid and 2% glutaraldehyde to animals and laborers.