The RAGE-A? interaction and its effects on pathogenesis of Alzheimers disease / 中国药理学通报
Chinese Pharmacological Bulletin
;
(12)1986.
Article
in Chinese
| WPRIM
| ID: wpr-565440
ABSTRACT
Receptor for advanced glycation end products(RAGE) is a member of the immunoglobulin superfamily.In central nervous system,RAGE is mainly expressed by neurons,microglia,and cerebral endothelial cells.In Alzheimers disease(AD) brain,levels of RAGE are significantly increased from the positive feedback mechanisms driven by excess amounts of ?-amyloid protein(A?).The interaction of RAGE with A? in neurons,microglia,and cerebral endothelial cells induces the perturbation of neuronal functions,amplification of microglia inflammatory responses,and vascular dysfunction.Further understanding the molecular mechanisms associating RAGE-A? interaction provides us the opportunity to develop the therapeutic approaches for the devastating disease.
Full text:
Available
Index:
WPRIM (Western Pacific)
Type of study:
Etiology study
Language:
Chinese
Journal:
Chinese Pharmacological Bulletin
Year:
1986
Type:
Article
Similar
MEDLINE
...
LILACS
LIS