Progress in studies on senescence accelerated mouse prone 8(SAMP8) / 中国药理学通报
Chinese Pharmacological Bulletin
;
(12)1986.
Article
in Chinese
| WPRIM
| ID: wpr-565637
ABSTRACT
The senescence accelerated mouse prone 8 strain was developed through phenotypic selection from a common genetic pool of AKR/J strain of mice.The SAMP8 strain exhibits age-related deterioration in memory and learning as well as A? accumulation early in its lifespan,and it is considered as an effective model for studying Alzheimer′s disease(AD).The SAMR1 strain(senescence accelerated resistant) is control,which exhibits normal aging characteristics.The present studies of SAMP8 have focused on revealing mechanism of accelerated deficits in learning and memory,and evaluating the efficiency of therapeutic drugs against AD.
Full text:
Available
Index:
WPRIM (Western Pacific)
Type of study:
Prognostic study
Language:
Chinese
Journal:
Chinese Pharmacological Bulletin
Year:
1986
Type:
Article
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