Contrast Study of the Effect of Urotensin Ⅱ Receptor Antagonist on the Plasma Urotensin Ⅱ in Rats of Acute Lung Injury / 医学研究杂志

ABSTRACT

Objective To investigate the alteration of urotensin Ⅱ in plasma of acute lung injury(ALI)rats,which affected by the urotensin Ⅱ receptor antagonist(URA),and to study the function of URA to ALI.Methods Forty-two Sprague Dawley(SD)rats were divided into two groups randomly,with each containing 21 rats.All rats were injected with oleic acid for ALI models.G1 as ALI model group,the other group was injected with URA as experiment group(G2).2 ml blood was drawn in 3,12,24 hours after injection,with each time blood being drawn in seven rats of each group.Plasma was separated from the blood.Keep plasma in-80℃ to be detected.Results The concentration of UⅡ of G1 in 3,12,24hours was(105.57?9.52)pg/ml,(119.30?8.30)pg/ml,(133.33?9.65)pg/ml,respectively;and(133.65?8.89)pg/ml,(131.99?9.80)pg/ml,(114.03?9.12)pg/ml in the same time of G2.With the time going on,the plasma concentration of UⅡwas significantly increased(P