Transplantation of haploidentical hematopoietic stem cells from family members without in vitro T-cell depletion for treatment of hematologic malignancies in pediatric patients / 北京大学学报(医学版)
Journal of Peking University(Health Sciences)
;
(6)2004.
Article
in Chinese
| WPRIM
| ID: wpr-565822
ABSTRACT
Objective:
To evaluate the efficacy and safety of haploidentical(from family member donors) hematopoietic stem cell transplantation(HSCT) for children with hematologic malignancies.Methods:
Fifty-eight children under fourteen years with hematological malignancies underwent haploidentical HSCT.All patients had poor-risk clinical or cytogenetic features and reclassified into high-risk and standard-risk groups.Transplantation outcomes were analyzed.Results:
Of fifty-eight patient/donor pairs,seven(12.1%) were mismatched in two HLA loci,twenty(34.5%) in three loci,and thirty-one(53.4%) in four loci.Follow-ups were performed for a median of 1 663(752-2 664) days after transplantation.All patients achieved stable engraftments.The cumulative incidence of acute graft-versus-host disease(GVHD) of grades 2-4 was(54.8?7.6)%,and that of grades 3-4 was(11.4?4.8)%.The cumulative incidence of chronic GVHD was(45.6?7.8)% for the total and(19.6?6.5)% for the extensive.Thirty-eight patients survived with a 2-year actual overall rate of survival 59.0% and 78.9% in the high-risk and standard-risk group,respectively.The 3-year probability of LFS was(58.6?8.0)% and(68.4?10.7)%,respectively.Conclusion:
The results encourage extending haploidentical HSCT without T-cell depletion treatments to children with an indication for transplantation.
Full text:
Available
Index:
WPRIM (Western Pacific)
Language:
Chinese
Journal:
Journal of Peking University(Health Sciences)
Year:
2004
Type:
Article
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