Effects of nanoscale titanium dioxide on intercellular gap junction communication in human lung fibroblasts / 北京大学学报(医学版)
Journal of Peking University(Health Sciences)
;
(6)2004.
Article
in Chinese
| WPRIM
| ID: wpr-565826
ABSTRACT
Objective:
To investigate the effects of nanoscale titanium dioxide(Nano-TiO2) on gap junctional intercellular communication(GJIC) between human lung fibroblasts.Methods:
Human lung fibroblasts were exposed to two different sizes Nano-TiO2(25 nm and 80 nm) for 24 hours at the concentrations of 0,10,20,40 and 80 mg/L,respectively.The GJIC between cells was measured by using fluorescence redistribution after photobleaching(FRAP) assay.Results:
The results showed that GJIC between cells was significantly inhibited both by 25 nm and 80 nm Nano-TiO2 in a dose-dependent manner.The fluorescence recovery rate was 20.81%?1.93% in control group,7.26%?0.91%(P
Full text:
Available
Index:
WPRIM (Western Pacific)
Language:
Chinese
Journal:
Journal of Peking University(Health Sciences)
Year:
2004
Type:
Article
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