Combined effects of rhBMP-2 and rhVEGF coated onto implants on osseointegration: pilot study / 대한치과보철학회지
The Journal of Korean Academy of Prosthodontics
;
: 82-89, 2013.
Article
in Korean
| WPRIM
| ID: wpr-56594
ABSTRACT
PURPOSE:
The present study is aimed to evaluate the combined effect of recombinant human bone morphogenetic protein 2 (rhBMP-2) and recombinant human vascular endothelial growth factor (rhVEGF) coated onto anodized implants on osseointeration. MATERIALS ANDMETHODS:
Six New Zealand white rabbit were used in this study. Each animal received 4 implants that were either coated with rhBMP-2 and rhVEGF (Study group) or anodized implant (Control group) in both tibia. This was performed using a randomized split-mouth design. A total 24 implants were used. The implant stability quotient (ISQ) value using resonance frequency analyser and removal torque (RTQ) measurement were investigated at 2 and 8 weeks. The t-test was used for statistical analysis (alpha=.05).RESULTS:
Control and study group showed good osseointegration at 8 weeks. The ISQ and RTQ values of study group were significant compared with the control group at 8 weeks (P.05).CONCLUSION:
It was concluded that rhBMP-2 with rhVEGF coated onto anodized implants can induce better osseointegration at late healing period.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Tibia
/
Pilot Projects
/
Osseointegration
/
Torque
/
Vascular Endothelial Growth Factor A
/
Bone Morphogenetic Protein 2
/
New Zealand
Type of study:
Controlled clinical trial
Limits:
Animals
/
Humans
Country/Region as subject:
Oceania
Language:
Korean
Journal:
The Journal of Korean Academy of Prosthodontics
Year:
2013
Type:
Article
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