The benefit of ertapenem on hospital ecology / 中国实用内科杂志

ABSTRACT

Resistance to antibiotic therapy is a worldwide problem with severe clinical and economic consequences.Among hospitalized patients,antibiotic resistance has been associated with increases in morbidity and mortality,prolonged hospitalization,and increased hospital costs.An important cause of antibiotic resistance is the selection of resistant bacterial strains as a result of inappropriate and/or excessive antibiotic prescribing in the hospital setting;important strategies to control resistance include monitoring and auditing drug use as well as surveillance and reporting of resistance patterns among hospital flora.Traditional antibiotics,such as cephalosporins and fluoroquinolones,are often linked to the emergence of multidrug-resistant gram-negative bacteria,particularly acinetobacter and pseudomonas spp,and increasingly,enterobacteriaceae.Accordingly,the treatment strategy is to think to choose an antibiotics with adequate infection control and lower resistance selection.Studies of relation between antibiotic consumption and antibiotic resistance show that ertapenem,a group 1 carbapenem,can not reduce the susceptibly of other antibiotics to pseudomonas spp,enterobacteriaceae and the others,and be benefit on hospital ecology. AbstractSumm aryResistance to antib iotic therapy is a worldw ide prob lem w ith severe c lin ical and econom ic consequences.A-mong hosp italized patients,antib iotic resistance has been assoc iated w ith increases in morb id ity and mortality,prolonged hosp italization,and increased hosp ital costs.An important cause of antib iotic resistance is the selection of resistant bacteri-al strains as a resu lt of inappropriate and /or excessive antib iotic prescrib ing in the hosp ital setting;important strategies to control resistance inc lude mon itoring and aud iting drug use as well as surve illance and reporting of resistance patterns a-mong hosp ital flora.Trad itional antib iotics,such as cephalosporins and fluoroqu inolones,are often linked to the em ergence ofmu ltidrug-resistant gram-negative bacteria,particu larly ac inetobacter and pseudomonas spp,and increasingly,enterobac-teriaceae.Accord ingly,the treatm ent strategy is to th ink to choose an antib iotics w ith adequate infection control and lower resistance selection.Stud ies of relation between antib iotic consumption and antib iotic resistance show that ertapenem,a group 1 carbapenem,can not reduce the susceptib ly of other antib iotics to pseudomonas spp,enterobacteriaceae and the others,and be benefit on hosp ital ecology.