Effects on weights and lipid of obese rats by combination of puerarin and glucose tolerance factor(GTF) at molecular level / 中华中医药杂志

ABSTRACT

Objective:TCM Gegen extract(puerarin)and glucose tolerance factor(GTF) can regulate glucose metabolism and lipid metabolism.The purpose of research is to observe effect of the comoles compound of puerarin and GTF at molecular level on diet-induced obesity in rats.Methods:Male SD obese rats,induced by high fat feed,were randomly divided into fi ve groupsobese model group,positive medicine control group,the groups with small,middle and large of puerarin and GTF,and normal control group.The rats were given medicine for four weeks,body weight of every week,and lipid were measured.Results:After being fed the comoles compound of puerarin and GTF at molecular level for four weeks,the weight growth of rats was slowed down,the level of the following quotaTG,TC,serum insulin and serum leptin declined,the level of HDL-C increased.Compared with obese model group,there was a difference(P