Effects of Rhein on resistin mRNA expression of adipose tissue and plasma free fatty acid in diabetic obese rats / 中华中医药杂志

ABSTRACT

Objective:To investigate the mechanism of therapeutic effects of Rhein on insulin resistance from aspects of the expression of resistin mRNA and plasma free fatty acid(FFA) in diabetic obese rats.Methods:The streptozotocin(STZ) and high fat diet-induced diabetic obese rats were divided into three groups at random.They were differently treated with Rhein,pioglitazone and saline by gavage.The expressions of resistin mRNA,plasma free fatty acid(FFA),as well as blood lipid in all groups were detected after administration by gavage for 8 weeks.Results:Similar to pioglitazone,Rhein can reduce the expression of resistin mRNA and the level of FFA,TC,TG and LDL(P