Effect of intravenous infusion of lidocaine on return of bowel function and stress response after hysterectomia surgery / 中国临床药理学与治疗学

ABSTRACT

AIM:To investigate the effect of intravenous infusion of lidocaine on postoperative pain,return of bowel function and stress response after hysterectomia surgery. METHODS:Sixty patients scheduled to undergo hysterectomia surgery were randomly divided into two groups with thirty in each group. Group L received intravenous lidocaine bolus injection of 1.5 mg/kg at induction of anesthesia,then continuous infusion of 1 mg?kg-1?h-1 intraoperatively and infusion of 100 mg plus sulfentanyl 50 mg for 48 h postperatively. Group S received an equal volume saline and infusion of sulfentanyl 100 mg for 48 h postperatively. Postoperative pain score at rest and cough were recorded by VAS. The times of first flatus,enterocinesia were recorded and the levels of motilin,cortisol and serum glucose were measured. RESULTS:Lidocaine significantly reduced postoperative pain,nause and vomit scores. Times to first flatus,enterocinesia were significantly shorter in patients who received lidocaine. the levels of motilin were significantly higher,but the levels of cortisol and serum glucose were significantly lower in Group L than in Group S. CONCLUSION:Intravenous lidocaine relieves postoperative pain,improve bowel function through increasing plasma motilin levels and decreasing stress responses after hysterectomia surgery.