Study on pharmacokinetics of brucine from normal and ultra-micro powder of semen strychni in rats / 中华中医药杂志
China Journal of Traditional Chinese Medicine and Pharmacy
;
(12)2005.
Article
in Chinese
| WPRIM
| ID: wpr-566713
ABSTRACT
Objective:
To study the pharmacokinetic process ofbrucine from normal and ultra-micro powder ofsemen strychni in rat serum.Methods:
HPLC techniques were used.All pharmacokinetics parameters were calculated with a 3P87 program.Results:
The pharmacokinetics results indicated that the normal powder and the ultra-micro powder ofsemen strychni belonged to two compartment open model.The absorb ofbrucine was just several ten minutes, and there was no obvious difference ofTmax between normal powder and ultra-micro powder.This showed thatBrucine was some material that was easily absorbed.But we can find that Cmax increased from(51.13?0.48)?g/L to(69.26?1.40)?g/L after ultra-micro powder preparation which was quite obvious.K,Ka,B and ? had a obvious increase(P
Full text:
Available
Index:
WPRIM (Western Pacific)
Language:
Chinese
Journal:
China Journal of Traditional Chinese Medicine and Pharmacy
Year:
2005
Type:
Article
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