Effect of Lingqi Capsule on expression VEGF,MMP-2 and MMP-9 in A549 cell / 中华中医药杂志
China Journal of Traditional Chinese Medicine and Pharmacy
;
(12)2005.
Article
in Chinese
| WPRIM
| ID: wpr-566719
ABSTRACT
Objective:
In occurrence and development process oflung cancer, the only known angiogenesis is one element ofthe growth, proliferation and aversion oftumor cells.VEGF, MMP-2 and MMP-9 play important role in the development and aversion ofA549 cell.This experiment is to reveal the effect ofLingqi Capsule on expression VEGF, MMP-2 and MMP-9 in A549 cell and mechanism ofanti-tumor.Methods:
Medicated serum was prepared with serum-pharmacology methods, the the effect ofmedicated serum on VEGFmRNA and protein expressions ofMMP-2 and MMP-9 was detected by RT-PCR technology and immunohistochemistry respectively.Results:
It suggested that the VEGF mRNAcorrect value ofthe administration group was respectively(0.804?0.020),(0.836?0.022)and(0.914?0.009),the blank control group was(0.905? 0.033)and positive control group was(0.766?0.014).Difference between the administration group and the blank control group was significant(P
Full text:
Available
Index:
WPRIM (Western Pacific)
Language:
Chinese
Journal:
China Journal of Traditional Chinese Medicine and Pharmacy
Year:
2005
Type:
Article
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