Effects of the Traditional Chinese Drug Chaiyuwendantang(CYWDT) and Its Component on the Plasm Levels of ACTH,COR and cAMP in Hippocampus of Depressed Mode / 浙江中医药大学学报
Journal of Zhejiang Chinese Medical University
;
(6)2007.
Article
in Chinese
| WPRIM
| ID: wpr-566908
ABSTRACT
[Objective] To explore the effects of the traditional Chinese drugs Chaiyuwendantang(CYWDT) and its component on the plasm levels of ACTH,COR and cAMP in hippocampus of depressed mode.[Methods] Eighty——four male rats were divided into seven groups control group,depressed model group,group of CYWDT,group of HuaTan,group of TiaoQiXue,group of YangXinPi,group of maprotiline equally and made up models in chronic unpredictable mild stress(CUMS).The plasm levels of ACTH,COR and the level of cAMP in hippocampus were detected by radioimmunoassay.[Results] We found that the plasm levels of ACTH,COR were significantly increase and cAMP in hippocampus was significantly decreasd in depression model of rat.CYWDT and TiaoQiXue could significantly decreased the level of ACTH(P
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Index:
WPRIM (Western Pacific)
Language:
Chinese
Journal:
Journal of Zhejiang Chinese Medical University
Year:
2007
Type:
Article
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