The Research of Multi-factors Combination to Induce Lung-Yang Deficiency Rats / 浙江中医药大学学报

ABSTRACT

[Objective]We established a model of Lung-Yang Deficiency.[Methods]The factors such as smoking(exogenous evil effect on lung),swimming in ice water(cold body and exhaustion),swimming in common water(exhaustion),and taking the methimazole ice solution(immune suppression and inhale cold)were adopted to establish this Lung-Yang Deficiency model.SD rats were treated for 35 days,and their physical signs(diet changes,drinking and other typical symptoms)were observed.The hemorheological parameters of the treated animals were measured.[Results]At the later period,rats in the Lung-Yang Deficiency model showed several symptoms,such as wheeze,breathlessness,meanwhile,accompanied with dullness,drinking less water,chill.Compared with the normal group,the body weight and the back temperature of the treated rats were decreased significantly.The whole blood viscosity(WBV)and whole blood reduced viscosity(WBRV)on the low shear rate were significantly increased from the normal.So was found the rigidity finger,deformed finger and electrophoresis finger of RBC parameters.[Conclusion]This model is fit to the clinical investigation of Lung-Yang Deficiency,resulting in that our method for model establishment is feasible.