Growth differentiation factor-15 in cardiovascular disease:from bench to bedside / 第二军医大学学报

ABSTRACT

Growth differentiation factor(GDF)-15,a distant member of the transforming growth factor-? cytokine superfamily,is a powerful cardioprotective factor.Many studies have demonstrated that serum GDF-15 level is a novel marker closely associated with the diagnosis,risk stratification,and prognosis of several cardiovascular diseases.This article mainly reviews the characteristics of GDF-15 and its multifunction in cardiovascular diseases.