Dual-role regulations of canonical Wnt/?-catenin signaling pathway / 北京大学学报(医学版)

ABSTRACT

In recent years,Wnt/?-catenin signaling has been identified as a key player in embryogenesis and human diseases.Canonical Wnt signaling pathway is controlled by a variety of classic molecules like Wnt,?-catenin,Axin,APC,GSK-3? and CK1,which interact and coordinate to regulate the expressions of cell signaling molecules.The latest evidences suggest that some components of the Wnt/?-catenin signaling,like APC,GSK-3?,CK1,Dkk2 and WISE,play dual roles different from what they have been thought previously.Here we reviewed some recent discoveries on the canonical Wnt/?-catenin signaling pathway to provide some new ideas and principles for signaling transduction studies.