Airway hyperresponsiveness among workers exposed to isocyanates at Yeocheon petrochemical plant / 천식및알레르기
Journal of Asthma, Allergy and Clinical Immunology
;
: 468-475, 1999.
Article
in Korean
| WPRIM
| ID: wpr-56746
ABSTRACT
OBJECTIVE:
To investigate the prevalence of airway hyperresponsiveness induced by isocyanate at one petrochemical industry complex in Yeochon, Korea.METHOD:
Questionnaires, allergic skin prick test, toluene diisocyanate (TDI)-specific IgE, and non-specific airway hyperresponsiveness (AHR) were studied in 73 exposed workers and 27 control subjects. Methacholine challenge tests were done and bronc hial responsiveness (BR index) was defined as log (% fall of FEV1)/ log (last concentration of methacholine +10).RESULTS:
Twenty-three workers (31.5% ) had respiratory symptoms, 21 had nasal symptoms, and eight had skin symptoms. Exposed workers with respiratory symptoms (n=22) had significantly higher BR index than those without them (0.82+/-0.06 vs 0.60+/-0.02, p0.05). Specific IgE antibodies were found in 19.7% of exposed workers. FEV, showed a significant negative correlation with BR index (r =-0.25, p<0.05). Poor correlation was noted between BR index and atopy, smoking status, or exposure duration.CONCLUSION:
These findings suggest that workers exposed to isocyanates are at higher risk of airway hyperresponsiveness.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Plants
/
Skin
/
Smoke
/
Immunoglobulin E
/
Smoking
/
Prevalence
/
Surveys and Questionnaires
/
Methacholine Chloride
/
Isocyanates
/
Toluene 2,4-Diisocyanate
Type of study:
Prevalence study
Country/Region as subject:
Asia
Language:
Korean
Journal:
Journal of Asthma, Allergy and Clinical Immunology
Year:
1999
Type:
Article
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