Effect of Cortex Phellodendron on Nephritic Rats' Tumor Necrosis Factor Alpha and Cyclooxygenase 2 / 浙江中医药大学学报

ABSTRACT

[Objective]To observe the effect and mechanism of cortex phellodendron on uric acid nephropathy.[Methods]32 male SD rats were divided into four groups including control group,model group,cortex phellodendron treated group and allopurinol treated group.Uric acidnephropathy model rats were established by using yeast and adenine,then treated with Sodium Chloride,cortex phellodendron or allopurinol respectively for 30 days.Blood urea nitrogen(BUN),creatinine(Cr),uric acid(UA)in blood were examined,and the expressions of tumor necrosis factor alpha(TNF-?)and cyclooxygenase 2(COX-2)in renal tissue were detected by immunohistochemistry technique.[Results]Compared with model group,the levels of BUN,Cr,UA in blood and the expression of COX-2 and TNF-? in renal tissue in cortex phellodendron treated group decreased significantly.[Conclusion]Cortex phellodendron has a beneficial effect on uric acid nephropathy in rats.It could decrease the expression of TNF-? and COX-2 in renal tissue of uric acid nephropathy rats so as to alleviate the damage of kidney and protect renal function.