ANALGESIC ACTION OF LITHIUM SALT IN RAT CAUDATE-PUTAMEN NUCLEUS / 重庆医科大学学报
Journal of Chongqing Medical University
;
(12)1986.
Article
in Chinese
| WPRIM
| ID: wpr-567611
ABSTRACT
Effect of lithium salt(Li)administnation to caudate-putamen nucleus (CPN) on pain response in the rat was studied by chronic cannula implantation and direct injection of drugs into the brain structurementioned above. The results were as follows( 1 ) The injection of Li into anterior part of the head of CPN of rats produced significantly the analgesic effect that could be antagonized by naloxone, atropine,phento-lamine.propranolol, lysergic acid diethylamide and bicuculline, but not by haloperidol.(2) The injection of Li into central part of the head of CPN of rats did not produce analgesic effect.The results above showed that microinjection of Li into different parts of the head of CPN could give rise to different effects on pain response and the analgesic effect of Li could be related to metabolic changes of endogenous opioid peptides, acetylcholine, noradrenaline, gama aminobutyric acid and 5-hydroXytryptamin aad mediated by their receptors respectively
Full text:
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Index:
WPRIM (Western Pacific)
Language:
Chinese
Journal:
Journal of Chongqing Medical University
Year:
1986
Type:
Article
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