Effects of combined application of thrombolytic therapy and aspiration thrombectomy on no-reflow phenomenon in patients with ST-segment elevation acute myocardial infarction after primary percutaneous coronary intervention / 解放军医学杂志

ABSTRACT

Objective To assess the effects of combined application of thrombolytic therapy and aspiration thrombectomy on no-reflow phenomenon in patients with ST-segment elevation acute myocardial infarction (AMI) after primary percutaneous coronary intervention (PCI). Methods Five hundred and thirty four patients with ST-segment elevation AMI,admitted from 2007 to 2010 and successfully treated with primary angioplasty within 24 hours after the onset of AMI,were divided into 4 groupsA group (without thrombolytic therapy combined with aspiration thrombectomy treatment),B group (only thrombolytic therapy),C group (only aspiration thrombectomy) and D group (treated with thrombolytic therapy and aspiration thrombectomy). All clinical,angiographic and procedural data were collected. Multiple logistic regression analysis was used to identify the related predictors of the no-reflow phenomenon. Results The no-reflow phenomenon was found in 138 (25.8%) of 534 patients. The incidence of no-reflow phenomenon in A,B,C,and D group was 32.7% (85/260),20.8% (20/96),21.7% (31/143) and 5.7% (2/35) (P=0.009),respectively. Conclusion Combined application of thrombolytic therapy and aspiration thrombectomy may significantly decrease the incidence of no-reflow phenomenon in patients with ST-segment elevation AMI and treated with primary PCI.