Effect of mitochondrial permeability transition pore on diabetic cardiomyopathy / 解放军医学杂志

ABSTRACT

Objective Diabetic mellitus is one of the major threats to human health.The prevalence of diabetes mellitus is growing rapidly worldwide.Patients with diabetes mellitus are at increased risk for cardiovascular diseases.Diabetic cardiomyopathy (DC) is related to diabetes-specific metabolism,but the mechanism is not entirely clear.Recent studies suggest that abnormal myocardial energy metabolism and reduced number of myocardial cells may be the important pathophysiological mechanism that leads to heart function impairment of diabetes patients.Mitochondria are not only an important place generating cellular energy,also involved in the apoptotic and death process of cells.Therefore,mitochondrial dysfunctions play a key role in the process of DC.Mitochondrial permeability transition (MPT) is a center for information exchange within and outside the mitochondria and plays a key role in the maintenance of mitochondrial function.MPT works through the mitochondrial permeability transition pore (MPTP).In our recent studies,it was found that MPTP function changed in DC and its abnormality could be corrected by specific AT I receptor antagonist.These findings are important for better understanding DC.