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Effects of Maijun'an Tablets on expression of ET-1 and NOS in spontaneous hypertensive rats / 中华中医药杂志
China Journal of Traditional Chinese Medicine and Pharmacy ; (12)2005.
Article in Chinese | WPRIM | ID: wpr-567881
ABSTRACT

Objective:

To investigate the effects of Maijun'an Tablets on expression of endothelin-1(ET-1) and nitricoxide synthase(NOS) in tissues and plasma of spontaneous hypertensive rats (SHR).

Methods:

12 spontaneous hypertensive rats (SHR) were divided randomly into normal control group and drug administration group. Rats in drug administration group were orally given with Maijun'an Tablets (hydrochlorothiazide 10 mg?kg-1.d-1,puerarin 36 mg?kg-1.d-1 and total alkaloid of rhynchophylla 122 mg?kg-1.d-1) once a day for 4 weeks,and rats in control group were orally dosed with equal amount of physiological saline. All animals were sacrificed after 4 weeks. The mRNA and protein contents of ET-1 and NOS in plasma,liver,kidnay and blood vessel were determined.

Results:

Compared with the control group,Maijun'an Tablets can effectively reduce blood pressure of SHRs,regulate down the content of ET-1 and regulate up the content of NOS at mRNA and protein levels.

Conclusion:

The up-regulation of NOS and down-regulation of ET-1 at mRNA and protein levels were the major antihypertensive machnisam of Maijun'an Tablets for SHRs.

Full text: Available Index: WPRIM (Western Pacific) Language: Chinese Journal: China Journal of Traditional Chinese Medicine and Pharmacy Year: 2005 Type: Article

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Full text: Available Index: WPRIM (Western Pacific) Language: Chinese Journal: China Journal of Traditional Chinese Medicine and Pharmacy Year: 2005 Type: Article