Comparative study on antitumor activity in vivo of Rhizoma Typhonii before and after processing / 中华中医药杂志

ABSTRACT

Objective:To compare antitumor activity in vivo of Rhizoma Typhonii before and after processing. Methods:To observe the effect of water decoction and ethanol extract from Rhizoma Typhonii before and after processing on the sarcoma grafts and immune organs of S180 mice by using mice transplant tumor model. Results:The results showed that both of the Rhizoma Typhonii and processed Rhizoma Typhonii had antitumor effect,and the former was stronger than the latter. The extract from processed Rhizoma Typhonii can inhance the immune function of mouse at some extent. Compared with control group,the Rhizoma Typhonii before processing had no effect in prolonging the life of tumor-bearing mouse. But,the ethanol extract from processed Rhizoma Typhonii can prolong the life of S180 mouse. Conclusion:Decoction and ethanol extract from Rhizoma Typhonii and processed Rhizoma Typhonii had antitumor effect. Processed Rhizoma Typhonii can enhance immune function and increase in life span on S180 mice,So processed Rhizoma Typhonii should be used in clinical medicine.