Up-regulation of TLR4 in the gut of rats after traumatic brain injury / 肠外与肠内营养
Parenteral & Enteral Nutrition
;
(6)1997.
Article
in Chinese
| WPRIM
| ID: wpr-567945
ABSTRACT
Objective:
The aim of the current study was to explore the alterations of TLR4 after traumatic brain injury.Methods:
20 Male ICR rats were randomly divided into four groups(5 rats each group)including control group without brain injury and traumatic brain injury groups(4,24 hours and 7 days).All rats were decapitated at corresponding time point and mid-jejunum samples were taken.The intestinal mucosa structure was detected by histopathological examination.Immunohistochemistry and realtime RNA were used for detection of TLR4 expression in ileum samples.Results:
After traumatic brain injury,the histopatholocal alterations of gut mucosa occurred at 4 hours and progressed to a serious state.Compared to control group,TLR4 was significantly up-regulated on the endothelia of microvessels in villous interstitium and lamina propria by 4 h following TBI and maximally expressed at 24 h post-injury.The endothelial TLR4 immunoreactivity in ileum mucosa still remained strong on 7 d post-injury.There was a very low mRNA expression of TLR4 in the gut of control rats and significantly increased at 4 h following TBI(P
Full text:
Available
Index:
WPRIM (Western Pacific)
Language:
Chinese
Journal:
Parenteral & Enteral Nutrition
Year:
1997
Type:
Article
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