Relationship between amnestic effect of ketamine,propofol or sodium oxybate and NMDA receptor / 中国药理学通报

ABSTRACT

Aim To investigate the relationship between amnestic effect of ketamine,propofol or sodium oxybate and NMDA receptor.Methods Amnestic model was established by intraperitoneal injection of ketamine (20 mg?kg~-1),propofol(10 mg?kg~-1) or sodium oxybate(100 mg?kg~-1) respectively in mice before intracerebroventricular injection of NMDA,and then the error times,step down latency and step through latency were observed in the step down test and step through test.Results NMDA by intracerebroventricular injection decreased the error times and increased the step down latency and step through latency of amnestic mice induced by ketamine.It had no significant impact on those of amnestic mice induced by propofol or sodium oxybate.Conclusion NMDA receptor may be an important target for amnestic effect of ketamine,rather than the target for amnestic effect of propofol or sodium oxybate.