Effect of Shenfu Injection on postoperation of mitral and aortic valve combined replacement / 中华中医药杂志

ABSTRACT

Objective: To investigate the effect of Shenfu injection on postoperation of mitral and aortic valve combined replacement surgery.Methods:46 cases, elective patients with mitral and aortic valve combined replacement in September 2008 to December 2009,were randomly assigned into two groups, the observation group 24 patients with the control group 22 patients. The Shenfu Injection, 50ml with 5% glucose injection 250ml,was used on postoperative day and 1-5day after that in the observation group. Other treatments were in the same with the control group patients. Monitoring pre and postoperative left ventricular end systolic diameter (LVSD),left ventricular end diastolic diameter (LVDD),left ventricular ejection fraction (LVEF),biochemicalmarkers of myocardial injury, dopamine dosage and the time of ventilator-assisted breathing. Results: The levels of reducing of left ventricular end systolic diameter and increasing of left ventricular ejection fraction in the observation group were higher than those in the control group(P