Study on the effect of Weichangshu Tablet on AchE and NO in rats with gastrointestinal dynamics / 中华中医药杂志

ABSTRACT

Objective: Investigating the effect of Weichangshu on gastrointestinal motility. Methods: Divide 50 Wistar rats into 5 groups randomly:normal control, model control, low dosage of Weichangshu, high dosage of Weichangshu, Cisapride, 10 in each group.In addition to the normal control group,the other four groups were prepared animal models of gastrointestinal motility disorder;the groups were given the same volume solution of medicine by way of gastric perfusion. for seven days, samples were taken from antrum and campylobacter after animals were anesthetized.AchE,NO were showed with immunohistocheinical method by SP.The optical density of myenteric plexues were measured with mitrosperegraph. Results: groups of Weichangshu can effectively increase AchE,NOS in gastro-intestinal tractl (P