PHARMACOKINETICES OF RANITIDINE IN NORMAL SUBJECTS / 重庆医科大学学报

ABSTRACT

The pharmacokinetics of ranitidine was studied with the method of high performance li-quid chromatography in 10 healthy volunteers. The subjects were given a single dose of ranitidine 150mg (one capsule) orally. The serum concentration-time curves showed that one-compartment open model could be used in all subjects. The equation of mean serum conccentration was and with following pharmacokinetic parameters (hr), and There were no statistically significant differences between the, kinetic parameters of reported articles and ours