Docetaxel-Induced Fatal Interstitial Pneumonitis in a Patient with Castration-Resistant Prostate Cancer
Korean Journal of Urology
;
: 371-374, 2012.
Article
in English
| WPRIM
| ID: wpr-56894
ABSTRACT
A 69-year-old man with castration-resistant prostate cancer (CRPC) received docetaxel and a corticosteroid. After the third cycle of docetaxel administration, he presented with dyspnea, cough, sputum, and fever of 39.2degrees C. The chest X-ray and chest computed tomography (CT) revealed a diffuse reticulonodular shadow in both lungs, which suggested interstitial pneumonitis. Initially, we used empiric broad-spectrum antibiotics and high-dose corticosteroids. However, his condition progressively became worse and he was transferred to the intensive care unit, intubated, and placed on mechanical ventilation. He died 4 days after hospital admission. Here we report this case of fatal interstitial pneumonitis after treatment with docetaxel for CRPC. We briefly consider docetaxel-induced pneumonitis to make physicians aware of the possibility of pulmonary toxicity so that appropriate treatment can be begun as soon as possible.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Pneumonia
/
Prostate
/
Prostatic Neoplasms
/
Respiration, Artificial
/
Sputum
/
Thorax
/
Adrenal Cortex Hormones
/
Lung Diseases, Interstitial
/
Cough
/
Taxoids
Limits:
Aged
/
Humans
Language:
English
Journal:
Korean Journal of Urology
Year:
2012
Type:
Article
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