CHANGES IN RGNTF AND ITS RECEPTOR IN HUMAN RETINOBLASTOMAL NUDE MICE MODEL AFTER IMMUNOTHERAPY / 解剖学报

ABSTRACT

We have used our retinal ganglion neuronotrophic factor (RGNTF) monoclonal antibody and anti-idiotypic antibody to study the immunohistochemical localization and quantitation of RGNTF and its receptor in the human retinoblastomal (Rb) nude mice model before and after RGNTF monoclonal antibody immunotherapy. The results revealed that for those nude mice responders treated with RGNTF monoclonal antibody and with Rb grade reduction, their RGNTF and receptor contents in Rb cells were reduced significantly from 100% before therapy to 32.4% and 25% after therapy, respectively. These quantitative results of RGNTF and its receptor contents between each grades differ significantly (P