Hypotensive Action of Cuzhuangnuzhen (Ligus trum robustum) / 中草药

ABSTRACT

When an extract of the leaves of Ligustrum robustum was given to anesthetized rats intravenously at doses of 0.098, 0.140, 0.200 g/kg the BP of the animals decreased rapidly by 37.7,38.6 and 50.2% respectively. But without any effect when given intragastrically to conscious rats at 1.36g/kg (qid ? 3d ). When conscious spontaneous hypertensive rats were given this extract intragastrically at 1.08 and 2.16g/kg (qid ?5d) their BP decreased to 18.1 ?0.9 and 16.6? 0.7kPa from 24.3?0.5 and 24.3?0.6kPa res pectively (P