Difference in Spinal Fusion Process in Osteopenic and Nonosteopenic Living Rat Models Using Serial Microcomputed Tomography
Journal of Korean Neurosurgical Society
;
: 348-354, 2017.
Article
in English
| WPRIM
| ID: wpr-56962
ABSTRACT
OBJECTIVE:
To identify and investigate differences in spinal fusion between the normal and osteopenic spine in a rat model.METHODS:
Female Sprague Dawley rats underwent either an ovariectomy (OVX) or sham operation and were randomized into two groups non-OVX group and OVX group. Eight weeks after OVX, unilateral lumbar spinal fusion was performed using autologous iliac bone. Bone density (BD) was measured 2 days and 8 weeks after fusion surgery. Microcomputed tomography was used to evaluate the process of bone fusion every two weeks for 8 weeks after fusion surgery. The fusion rate, fusion process, and bone volume parameters of fusion bed were compared between the two groups.RESULTS:
BD was significantly higher in the non-OVX group than in the OVX group 2 days and 8 weeks after fusion surgery. The fusion rate in the non-OVX group was higher than that in the OVX group 8 weeks after surgery (p=0.044). The bony connection of bone fragments with transverse processes and bone formation between transverse processes in non-OVX group were significantly superior to those of OVX group from 6 weeks after fusion surgery. The compactness and bone maturation of fusion bed in non-OVX were prominent compared with the non-OVX group.CONCLUSION:
The fusion rate in OVX group was inferior to non-OVX group at late stage after fusion surgery. Bone maturation of fusion bed in the OVX group was inferior compared with the non-OVX group. Fusion enhancement strategies at early stage may be needed to patients with osteoporosis who need spine fusion surgery.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Osteogenesis
/
Osteoporosis
/
Spinal Fusion
/
Spine
/
Ovariectomy
/
Bone Density
/
Rats, Sprague-Dawley
/
Models, Animal
/
X-Ray Microtomography
Type of study:
Controlled clinical trial
Limits:
Animals
/
Female
/
Humans
Language:
English
Journal:
Journal of Korean Neurosurgical Society
Year:
2017
Type:
Article
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