Effects of Jinma Tongluo Capsule on Micronucleus of Mice Marrow Cells / 中药新药与临床药理
Traditional Chinese Drug Research & Clinical Pharmacology
;
(6)1993.
Article
in Chinese
| WPRIM
| ID: wpr-569748
ABSTRACT
Effects of Jinma Tongluo capsule (JTC) on the incidence of micronucleus of marrow cells in mice with Kunming species were reported. JTC intragastric dosages of 100 mg/kg, 400 mg/kg, 1600 mg/kg (equivalent to 3, 12 and 48 times of the clinical dosage respectively) were given to the mice.Twenty-four hours later the mice were executed and the marrow cells were examined. The incidence of micronucleus was 2.00‰, 1.83‰, 2.17‰ respectively. In the group of dosage of 1600 mg/kg, the incidence was maintained in the normal limits within 12~72h. And the differences were not significant as compared with the negative group and the solvent control group. It's indicated that ig total alkalin of Flos Daturae under 0.86 mg/kg has no effect on micronucleus of mice marrow cells.
Full text:
Available
Index:
WPRIM (Western Pacific)
Language:
Chinese
Journal:
Traditional Chinese Drug Research & Clinical Pharmacology
Year:
1993
Type:
Article
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