Study on the Inclusion Compound of Baicalin with Hydroxypropyl-?-Cyclodextrin / 中成药
Chinese Traditional Patent Medicine
;
(12)1992.
Article
in Chinese
| WPRIM
| ID: wpr-569838
ABSTRACT
Objective:
To prepare the inclusion compund of baicalin-hydroxypropyl-?-cyclodextrin (HP-?-CD) and identify it.Methods:
The inclusion compound of baicalin-HP-?-CD was confirmed by freeze-drying method.Results:
The inclusion compound of baicalin-HP-?-CD was confirmed by IR absorption spectroscopy and differential scanning calorimetry (DSC). The results indicated that the inclusion compound of baicalin-HP-?-CD was formed. The content analysis of the inclusion compound showed that the molecular ratio of baicalin to HP-?-CD was 1∶1.Conclusion:
The solubility of baicalin is increased from 0.112mg/ml to 2.743mg/ml. when the drug is included by HP-?-CD.
Full text:
Available
Index:
WPRIM (Western Pacific)
Language:
Chinese
Journal:
Chinese Traditional Patent Medicine
Year:
1992
Type:
Article
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