The relation of vascular endothelial growth factor and angiogenesis to the progression of colorectal carcinoma / 中华消化杂志

ABSTRACT

Objective To investigate the relation of vascular endothelial growth factor (VEGF) and angiogenesis to the progression of colorectal carcinoma (CC). Methods VEGF protein expression and microvessel density (MVD) in 102 cases of human CC were examined by use of immunohistochemical staining. MVD and VEGF expression were analysed with their relation to histological grade, depth of invasion, Dukes stage, lymph node metastasis, liver metastasis and prognosis of CC. Results MVD was significantly higher in VEGF positive CC than in VEGF negative CC ( P