Actions of Immature Orange Fruit and Dried Tangerine Peel on the Tension of Isolated Aortic Muscle Strips / 中成药
Chinese Traditional Patent Medicine
;
(12)1992.
Article
in Chinese
| WPRIM
| ID: wpr-570031
ABSTRACT
Objective:
To study the effects of immature orange fruit(IOF) and dried tangerine peel(DTP) on the resting tension of isolated aortic muscle strips in rabbits and their mechanisms.Methods:
The organ-bath was used to observe the response of aortic strip to IOF and DTP.Results:
IOF and DTP dose-dependently increased the tension of aortic strip, and the action of IOF was more significant than that of the same concentration DTP. 10 -7 mol/L phentolamine, 10 -5 mol/L verapamil or incubation with Ca 2+ -free Krebs solution could block the effects of IOF and DTP partly, but 10 -6 mol/L diphenhydramine could not. In endothelium-removed aortic strips, the effects of IOF and DTP decreased after treatment with 10 -7 mol/L atropine.Conclusions:
IOF and DTP can contract vascular smooth muscle, which probably contribute to ? adrenergic receptor, cholinergic M receptor on membrane of vascular smooth muscle partly, and is dependent Ca 2+ influx through verapamil-sensitive Ca 2+ channels, but is not related to H 1 histamine receptor.
Full text:
Available
Index:
WPRIM (Western Pacific)
Language:
Chinese
Journal:
Chinese Traditional Patent Medicine
Year:
1992
Type:
Article
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