The expression of interleukin-17 in patients with ulcerative colitis / 中华消化杂志
Chinese Journal of Digestion
;
(12)2001.
Article
in Chinese
| WPRIM
| ID: wpr-570156
ABSTRACT
Objective To investigate the expression an d the role of interleukin 17(IL 17) in patients with ulcerative colitis (UC). Methods IL 17,IL 6 and IL 8 were measured using ELISA technique , and IL 17 mRNA was assayed by RT PCR in 32 patients with UC and compared with 40 controls. The effect of anti IL 17 m onoclonal antibody (MoAb) on production of IL 6 and IL 8 by lamina propria mo nonuclear cells (LPMC) was studied. Results As compared with controls, serum concentrations of IL 17 ,IL 6 and IL 8 from UC patients were significantly higher, but with no statist ic difference. The expression of IL 17 mRNA and secretion of IL 17 by the peripheral blood CD + 4 T cells in UC patients were higher than that in nor mal controls in the presence of stimuli (both P
Full text:
Available
Index:
WPRIM (Western Pacific)
Language:
Chinese
Journal:
Chinese Journal of Digestion
Year:
2001
Type:
Article
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