INFLUENCE OF PROGESTERONE ANTAGONIST-RU486 ON THE MACROPHAGES IN THE UTERI OF PREGNANT MICE AND ITS RELEVANCE TO PREGNANCY / 解剖学报
Acta Anatomica Sinica
;
(6)1953.
Article
in Chinese
| WPRIM
| ID: wpr-570281
ABSTRACT
Objective The experiment was conducted to explore the influence of progesterone antagonist\|RU486 on the macrophages in the uteri of pregnant mice and its relevance to pregnancy. Methods On day 4 and day10 of gestation, each mouse was subcutaneously injected with 150mg/L of RU486 (treatment group) or the same volume of saline (control group). The macrophages were immunohistochemically identified in the uterus 12, 24, 36?h after injection. Results Injection of RU486 on day 4 gestation had completely blocked the implantation of blastocysts. A large number of macrophages were found in the endometrium, myometrium and blood vessel layer 12~36?h after RU486 injection, which was significantly higher than that of the control groups ( P
Full text:
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Index:
WPRIM (Western Pacific)
Language:
Chinese
Journal:
Acta Anatomica Sinica
Year:
1953
Type:
Article
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