The experimental study on the effectiveness of intralesional injection of triamcinolone to urethral stricture / 대한비뇨기과학회지

ABSTRACT

Hypertrophic scars with proliferation of fibroblasts are noted in urethral stricture. Internal urethrotomy followed by intralesional injection of triamcinolone have been taken frequently to prevent recurrence of urethral stricture. To evaluate the effect of triamcinolone against stricture formation. we made iatrogenic urethral injury on two male dogs with one receiving simultaneous intralesional injection of triamcinolone and the other without injection. There were less inflammation. fewer granulation tissue formation (fewer fibroblast less capillary, less mucopolysaccharide deposit, less collagen) in early phase of wound healing and thinner fibrous scar tissue formation in later phase on the dog treated with triamcinolone injection than the doe without it. So. the effect of triamcinolone injection was thought to shorten the inflammatory response which resulted in small amount of granulation tissue with subsequently less degree of fibrous scar formation.