Effect of Combination of Rhizoma Coptidis and Fructus Evodiae in Various Proportions on Rat Models with Heat Syndrome Induced by Radix Codonopsis Pilosulae and Radix Astragali seu Hedysari / 广州中医药大学学报

ABSTRACT

[Objective] To observe the effect of combination of Rhizoma Coptidis (RC) and Fructus Evodiae (FE) in various proportions on rat models with heat syndrome. [Methods] Rat models with heat syndrome were set up by gastric infusion of Radix Codonopsis Pilosulae and Radix Astragali seu Hedysari. Fifty rats were allocated to five groups normal control group (Group A), model group (Group B), model rats treated with RC and FE at the proportion of 6∶1 (Group C), model rats treated with RC and FE at the proportion of 2∶1 (Group D) and model rats treated with RC and FE at the proportion of 1∶1 (Group E). [Results] Ultrastructure of hepatic cells were improved in Group C, Group D and Group E. Indexes of heat syndrome such as temperature, serum corticosteroid (Cor) level and 17 - hydroxycorticosteroid (17-OHCS) content in homogenate of adrenal glands were decreased in Group C and Group D but stayed unchanged in Group E as compared with Group B ( P