Study on moulding technics of Shuxin Drop Pills / 中成药

ABSTRACT

Objective: To find out the parameters of drop pill's process in proportion to matrix, refrigerant and addition, in relationship with the height and rotational speed of freeze-pillar and drop pills. Methods: Using parallel experimentation for the choice of matrix and refrigerant; mode and proportion of adding drug. Using orthogonal experimentation for the choice of height and rotate speed about freeze-pillar, dropping speed. With moulding probability of drop pills as the evaluation quota to decide the best dropping condition. Results: PEG 4000 is matrix. Methyl-siliconoil Liquid-paraffin (3∶1) is refrigerant. Internal and external diameter of burette are equal to 4.5mm and 5.8mm. Drug is dropped into the refrigerant of 10～15 ?C by 50 to 60 dropping per minute (freeze-pillar height 120cm, rotate speed is 20 round per minute.) Moulding probability is of the highest one. Conclusion: The moulding technics of drop pills with high finished product rate and good quality.